{"type":"standard","title":"Transglutaminase","displaytitle":"Transglutaminase","namespace":{"id":0,"text":""},"wikibase_item":"Q423646","titles":{"canonical":"Transglutaminase","normalized":"Transglutaminase","display":"Transglutaminase"},"pageid":991758,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Coagulation_factor_XIII_1EVU.png/330px-Coagulation_factor_XIII_1EVU.png","width":320,"height":348},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/c/cc/Coagulation_factor_XIII_1EVU.png","width":2384,"height":2592},"lang":"en","dir":"ltr","revision":"1247059206","tid":"9d21d8ef-78ff-11ef-b0af-dae22b7dbf20","timestamp":"2024-09-22T16:27:52Z","description":"Class of enzymes capable of forming isopeptide bonds in certain regions of proteins","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Transglutaminase","revisions":"https://en.wikipedia.org/wiki/Transglutaminase?action=history","edit":"https://en.wikipedia.org/wiki/Transglutaminase?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Transglutaminase"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Transglutaminase","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Transglutaminase","edit":"https://en.m.wikipedia.org/wiki/Transglutaminase?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Transglutaminase"}},"extract":"Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side chains and the ε-amino groups ( -NH2 ) of lysine residue side chains with subsequent release of ammonia ( NH3 ). Lysine and glutamine residues must be bound to a peptide or a protein so that this cross-linking (between separate molecules) or intramolecular (within the same molecule) reaction can happen. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). The reaction isGln-(C=O)NH2 + NH2-Lys → Gln-(C=O)NH-Lys + NH3","extract_html":"
Transglutaminases are enzymes that in nature primarily catalyze the formation of an isopeptide bond between γ-carboxamide groups ( -(C=O)NH2 ) of glutamine residue side chains and the ε-amino groups ( -NH2 ) of lysine residue side chains with subsequent release of ammonia ( NH3 ). Lysine and glutamine residues must be bound to a peptide or a protein so that this cross-linking (between separate molecules) or intramolecular (within the same molecule) reaction can happen. Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). The reaction is
- Gln-(C=O)NH2 + NH2-Lys → Gln-(C=O)NH-Lys + NH3
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{"type":"standard","title":"Christian Fletcher","displaytitle":"Christian Fletcher","namespace":{"id":0,"text":""},"wikibase_item":"Q5109601","titles":{"canonical":"Christian_Fletcher","normalized":"Christian Fletcher","display":"Christian Fletcher"},"pageid":24629463,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/8/86/The_Honours_Saved_From_Cromwell%2C_1652.JPG/330px-The_Honours_Saved_From_Cromwell%2C_1652.JPG","width":320,"height":244},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/8/86/The_Honours_Saved_From_Cromwell%2C_1652.JPG","width":2489,"height":1900},"lang":"en","dir":"ltr","revision":"1214143358","tid":"325c66f2-e422-11ee-8e3a-134c134c8081","timestamp":"2024-03-17T05:50:02Z","description":"Scottish noblewoman who saved the Honours of Scotland","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Christian_Fletcher","revisions":"https://en.wikipedia.org/wiki/Christian_Fletcher?action=history","edit":"https://en.wikipedia.org/wiki/Christian_Fletcher?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Christian_Fletcher"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Christian_Fletcher","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Christian_Fletcher","edit":"https://en.m.wikipedia.org/wiki/Christian_Fletcher?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Christian_Fletcher"}},"extract":"Christian Fletcher, Lady Abercrombie, was a Scottish minister's wife who helped save the Honours of Scotland from Cromwell's troops during the English invasion of Scotland. She was married from 1642 to James Granger, the Presbyterian minister of Kinneff Church.","extract_html":"
Christian Fletcher, Lady Abercrombie, was a Scottish minister's wife who helped save the Honours of Scotland from Cromwell's troops during the English invasion of Scotland. She was married from 1642 to James Granger, the Presbyterian minister of Kinneff Church.
"}{"slip": { "id": 46, "advice": "Try going commando to an important meeting, NB: don't wear a skirt."}}
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{"type":"general","setup":"Why didn't the skeleton go for prom?","punchline":"Because it had nobody.","id":396}
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